The One Direction star is on the cover the new issue Rolling Stone, for which he also took part in an interview with Cameron Crowe.
Cameron famously worked at the magazine before becoming a film director (Almost Famous, Jerry Maguire) and spent a few days with Harry for the prile.
During their time together, Harry discussed the meaning behind his lead single, Sign the Time, which debuted at number one on the UK Singles Chart and number 4 in the US.
"Most the stuff that hurts me about what's going on at the moment is not politics, it's fundamentals," he says.
"Equal rights. For everyone, all races, sexes, everything. ... 'Sign the Times' came from 'this isn't the first time we've been in a hard time, and it's not going to be the last time.' The song is written from a point view as if a mother was giving birth to a child and there's a complication. The mother is told, 'The child is fine, but you're not going to make it.'
"The mother has five minutes to tell the child, 'Go forth and conquer.'"
Harry also explained why he was the first one in One Direction to suggest a hiatus as well as talk about the meaning behind his new music.
"I wanted to step up," Styles explains. "There were songs I wanted to write and record, and not just have it be 'Here's a demo I wrote.' Every decision I've made since I was 16 was made in a democracy.
"I felt like it was time to make a decision about the future ... and maybe I shouldn't rely on others."
Harry will perform Sign the Times on The Graham Norton Show this Friday on BBC One. His debut album is out on May 12.